Over 50% of respondents self-diagnosed with “anxiety attacks” or “severe depression” reported using complementary and alternative therapies to treat their condition. Previous studies have demonstrated that psychiatric disorders are common among those seeking to use complementary and alternative medicine (CAM) and that anxiety and depression are among the most common reasons for people to seek care from complementary practitioners. Knowledge about the use of complementary therapies by people with mental illness is increasing. Further well-designed, well-reported trials that reflect practice may be worth pursuing. Despite promising results, particularly for Xiao Yao San and its modifications, the effectiveness of Chinese herbal medicine in depression could not be fully substantiated based on current evidence. However, limitations in methodology and reporting were revealed. Positive results were reported: no significant differences from medication, greater effect than medication or placebo, reduced adverse event rates when combined or compared with antidepressants. The supplementary review located 8 trials, 3 of which were not included in previous reviews. Five systematic reviews were located addressing the Chinese literature, adjunctive use of Chinese herbs, and the formulae Chaihu-Shugan-San, Xiao Yao San, and Free and Easy Wanderer Plus. Systematic reviews were identified and assessed using key criteria. Results were screened and selected trials were evaluated by two reviewers working independently. #Free and easy wanderer trialSearches were conducted using AMED, Cochrane Library, EMBASE, MEDLINE/PubMed, PsycINFO, and trial registers. The aim of this paper was to provide an overall picture of the current evidence by analysing published systematic reviews and presenting a supplementary systematic review of trials in Western databases. Alternative approaches for managing depression are often sought and herbal mixtures are widely used in China.
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